Erik Waage Nielsen

Professor II
Fakultet for sykepleie og helsevitenskap
Studiested
Bodø
Kontor
Bodø, Hovedbygning E247

Place of work: Nord University and Dep. of Anesthesiology Nordland Hospital N-8092 Bodø, NorwayTel: +47 75 53 40 00. Fax: +47 75 53 42 97. E-mail erik.waage.nielsen@gmail.com Position: Senior Consultant, Professor at the University of Tromsø (UiT), Nord University, Bodø, and University of Oslo, Norway (2014).

BRIEF SUMMARY:Cand.med. Medical Degree Oslo 1984. Authorized doctor 1986. Specialist in Anesthesiology 1995. Attending Physician 1994. Ph.D (Doctor.Med) 1996. Associate Professor 1997. Professor 2008

SCIENCE: I became interested in C1-inhibitor (C1€‘INH) deficiency when a young boy with edema of the mouth and throat was admitted on my duty at the Dep.of Pediatrics in 1987. The interest resulted in the disclosure of a large kindred with C1-inhibitor defiency and a thesis on Hereditary Angiodema. Since then the scope has broadened to the role C1€‘INH is playing in mediating capillary leakage in inflammation and sepsis, and the possible use of C1€‘INH concentrate in modulating reperfusion injury and prevention of hyperacute rejection of transplants.

Responsible for ANILAB, animal research facility at Nord University.

TEACHING/ADMINISTRATION: Assistent leader, Institute of Clinical Medicine, University of Tromsø with responsibilities for the education, practise and examination of medical students from UiT at Nordland Hospital 2009-until june 2018. The project was initiated by Northern Norway Regional Health Authority (Helse Nord)

Research Network -Member of the Norwegian Complement Research Group headed by Professor Tom Eirik Mollnes.

Member of a former European Union concerted action on Hereditary angioedema, Novel Methods For Predicting Preventing And Treating Attacks In Patients With Hereditary Angioedema (PREHAEAT). The project was lead by Professor Marco Cicardi, Milano, Italy.-Member of the research group Brakutan (https://sites.google.com/site/brakutan/) Publications: In total ca 140+ articles from 1989-today 17th August 2018 (134 hits on PubMed), https://www.ncbi.nlm.nih.gov/pubmed/?term=nielsen+ew+or+%22waage+nielsen%22

2024
Femoral Nailing in a Porcine Model Causes Bone Marrow Emboli in the Lungs and Systemic Emboli in the Heart and Brain 2024, JBJS Open Access: Volum 9;Kristiansen, Steinar; Jarmund, Anders Hagen; Hilmo, Jonas Larsen; Mollnes, Tom Eirik; Leth-Olsen, Martin; Nyrnes, Siri Ann
Real-time feedback on chest compression efficacy by hands-free carotid Doppler in a porcine model 2024, Resuscitation Plus: Volum 18;Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin Stage; Lappegård, Knut Tore; Nilsen, Bent Aksel; Kiss, Gabriel Hanssen
2023
Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model 2023, Resuscitation Plus: Volum 15:100412 s. 1-10;Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin; Lappegård, Knut Tore; How, Ole-Jakob; Nilsen, Bent Aksel
How should tranexamic acid be administered in hemorrhagic shock? continuous serum concentration measurements in a swine model 2023, Shock: Volum 60 s. 707-712;Lynghaug, Trine; Bakke, Håkon Kvåle; Fuskevåg, Ole Martin; Nielsen, Erik Waage; Dietrichs, Erik Sveberg
Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies 2023, Frontiers in Immunology: Volum 14:1230049 s. 1-26;Marsh, Phillip L.; Moore, Ernest E.; Moore, Hunter B.; Bunch, Connor M.; Aboukhaled, Michael; Condon, Shaun M.
2019
2017
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis 2017, Journal of Intensive Care: Volum 5:21 s. 1-9;Hellerud, Bernt C; Orrem, Hilde Lang; Dybwik, Knut Gustav; Pischke, Søren Erik; Barratt-Due, Andreas; Castellheim, Albert
Systemic inflammation in acute intermittent porphyria:a case–control study 2017, Clinical and Experimental Immunology: Volum 187 s. 466-479;Storjord, Elin; Dahl, Jim André; Landsem, Anne; Fure, Hilde; Ludviksen, Judith K; Goldbeck-Wood, Sandy
2015
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis 2015, Critical Care: Volum 19:415;Skjeflo, Espen Waage; Sagatun, Caroline; Dybwik, Knut; Aam, Sturla; Urving, Sven Haakon; Nunn, Miles A.
Nine out of ten trauma calls to a Norwegian hospital are avoidable: a retrospective analysis 2015, BMC Emergency Medicine: Volum 15;Stordahl, Harald; Passas, Evangelina Helene Tønsberg; Hopland, Andreas; Nielsen, Erik Waage
Massive organ inflammation in experimental and in clinical meningococcal septic shock 2015, Shock: Volum 44 s. 458-469;Hellerud, Bernt C; Olstad, Ole Kristoffer; Nielsen, Erik W.; Siebke, Anne-Marie; Skadberg, Øyvind; Thorgersen, Ebbe Billmann
A nationwide study of Norwegian patients with hereditary angioedema with C1 inhibitor deficiency identified six novel mutations in SERPING1 2015, PLOS ONE: Volum 10;Johnsrud, Irene Elizabeth; Kulseth, Mari Ann; Rødningen, Olaug Kristin; Landrø, Linn Aina Ysland; Helsing, Per; Nielsen, Erik Waage
Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients 2015, Metabolic Syndrome and Related Disorders: Volum 13 s. 119-124;Trøseid, Marius; Nestvold, Torunn Kristin; Nielsen, Erik Waage; Thoresen, Hanne E. G.; Seljeflot, Ingebjørg; Lappegård, Knut Tore
2014
Bradykinin analysis revived - A validated method for determination of its stable metabolite in whole blood by LC-MS/MS 2014, Journal of chromatography. B: Volum 947-948 s. 139-144;Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Nielsen, Erik Waage; Landrø, Linn Aina Ysland; Reubsaet, Leon
Fear of hypoglycemia in women and men with type 1 diabetes 2014, Nursing Research: Volum 63 s. 143-149;Gjerløw, Ellen; Bjørgaas, Marit Ragnhild Rokne; Nielsen, Erik Waage; Olsen, Sandra Elise; Åsvold, Bjørn Olav
Advantages of strain echocardiography in assessment of myocardial function in severe sepsis: An experimental study 2014, Critical Care Medicine: Volum 42 s. e432-e440;Hestenes, Siv Merete; Halvorsen, Per Steinar; Skulstad, Helge; Remme, Espen; Espinoza, Andreas Westenvik; Hyler, Stefan
2013
Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity: Evidence from bariatric surgery 2013, Diabetes Care: Volum 36 s. 3627-3632;Trøseid, Marius; Nestvold, Torunn Kristin; Rudi, Knut; Thoresen, Hanna; Nielsen, Erik Waage; Lappegård, Knut Tore
Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation 2013, Journal of Immunology: Volum 191 s. 4769-4777;Lau, Corinna; Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Andersen, Jan Terje; Berntzen, Gøril; Pharo, Anne Margrethe
2012
2010
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs 2010, The FASEB Journal: Volum 24 s. 712-722;Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Nielsen, Erik Waage; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine
Hematologic and Hemostatic Changes Induced by Different Columns During LDL Apheresis 2010, Journal of clinical apheresis: Volum 25 s. 294-300;Hovland, Anders Wilhelm; Hardersen, Randolf; Nielsen, Erik Waage; Mollnes, Tom Eirik; Lappegård, Knut Tore
Eldre mann med kjent hjertesvikt innlagt med kardiogent sjokk 2010, Tidsskrift for Den norske legeforening: Volum 130 s. 1352-1354;Hovland, Anders Wilhelm; Fagerheim, Ann-Kristin; Nielsen, Erik Waage; Hardersen, Randolf
Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity 2010, Innate Immunity: Volum 16 s. 254-264;Thorgersen, Ebbe Billmann; Ludviksen, Judith K; Lambris, John D.; Sfyroera, G; Nielsen, Erik Waage; Mollnes, Tom Eirik
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis 2010, Critical Care Medicine: Volum 38 s. 1467-1474;Hellerud, Bernt C; Nielsen, Erik Waage; Thorgersen, Ebbe Billmann; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Tønnessen, Tor Inge
2008
En 75 år gammel mann med nevrologiske symptomer etter sykkelvelt 2008, NAForum: Volum 21 s. 51-54;Nielsen, Erik Waage; Antal, EA; Alstadhaug, Karl Bjørnar; Mortensen, Liisa; Rucic, Zoran; Salvesen, Rolf
En 79 år gammel intensivpasient med ødem i hals og ansikt 2008, NAForum: Volum 21 s. 60-62;Skjeflo, Gunnar Waage; Urving, Sven Haakon; Nielsen, Erik Waage
2007
Candidate inhibitors of porcine complement 2007, Molecular Immunology: Volum 44;Thorgersen, Ebbe B; Ghebremariam, Yohannes T; Thurman, Joshua M; Fung, Michael; Nielsen, Erik Waage; Holers, V Michael
Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement 2007, Molecular Immunology: Volum 44;Nielsen, Erik Waage; Waage, Cristian; Fure, Hilde; Brekke, Ole Lars; Sfyroera, Georgia; Lambris, John D.
[Acute myocardial infarction in Bodo over a period of 15 years] 2007, Tidsskrift for Den norske legeforening: Volum 127 s. 1631-1633;Hovland, Anders; BjØrnstad, hanne; strømsnes, oddgeir; Nielsen, Erik Waage; Sexton, Joe
2023
Real Time Feedback of Chest Compressions by Hands-Free Carotid Doppler in a Porcine Model 2023, Circulation: Volum 148;Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin Stage; Lappegård, Knut Tore; How, Ole-Jakob; nielsen, bent aksel
2022
Low systemic concentrations of bupivacaine from topical anesthesia of the tonsillar beds after tonsillectomy 2022,;Seines, Ellisiv; Fretland, Bjørn; Gál, Peter; Berg, Kristin Sandal; Stubhaug, Audun; Løberg-Emanuelsen, L
2021
INTRAMUSCULAR UPTAKE OF TRANEXAMIC ACID DURING HEMORRHAGIC SHOCK IN A SWINE MODEL 2021,;Bakke, Håkon Kvåle; Fuskevåg, Ole Martin; Nielsen, Erik Waage; Dietrichs, Erik Sveberg
2020
Intramuscular uptake of tranexamic acid during haemorrhagic shock in a swine model 2020,;Bakke, Håkon Kvåle; Fauskevåg, Ole Martin; Nielsen, Erik Waage; Dietrichs, Erik Sveberg
2013
Key role of tissue factor in complement-mediated coagulation activation by Escherichia coli and LPS 2013, Molecular Immunology: Volum 56 s. 250-250;Brekke, Ole Lars; Landsem, Anne; Fure, Hilde; Christiansen, Dorte; Nielsen, Erik Waage; Lambris, J.D.
Investigating bradykinin exposure in hereditary angioedema through the metabolite BK1-5 2013,;Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Helsing, Per; Reubsaet, Leon
2012
Bradykinins rolle ved arvelig angiødemanfall – LC-MS/MS bestemmelse via metabolitten BK1-5 i fullblod 2012,;Bjerknes, Kari Christiane; Seip, Knut Fredrik; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Nielsen, Erik Waage; Reubsaet, Leon
The role of Bradykinin in attacks of angioedema - Development of a method for measuring the stable metabolite BK1-5 2012,;Bjerknes, Kari Christiane; Seip, Knut Fredrik; Reubsaet, Leon; Nielsen, Erik Waage; Johansen, Harald Thidemann
Investigating bradykinin exposure in hereditary angioedema through the metabolite BK1-5 2012,;Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Helsing, Per; Reubsaet, Leon
2008
Genetic complement deficiencies dissociate the roles of human complement in the inflammatory responses: Lessons from nature 2008, Molecular Immunology: Volum 45 s. 4145-4146;Lappegard, KT; CHRISTIANSEN, DANIELA; Pharo, Anne Margrethe; Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Lindstad, Julie Katrine
C1-inhibitor in meconium-induced complement activation and cytokine formation 2008, Neonatology: Volum 93 s. 335-336;Salvesen, Bodil; Nielsen, Erik Waage; Saugstad, Ola Didrik; Mollnes, Tom Eirik
2007
Oxidative burst in complement deficient patients: Lessons from nature 2007, Molecular Immunology: Volum 44 s. 3968-3968;Thorgersen, EB; Pharo, A; Lindstad, JK; Bergseth, G; Nielsen, Erik Waage; Lappegard, KT
Vaccinia virus complement control protein (VCP) is an efficient inhibitor of porcine complement 2007, Molecular Immunology: Volum 44;Thorgersen, Ebbe B; Ghebremariam, Yohannes T; Nielsen, Erik Waage; Kotwal, Girish J; Mollnes, Tom Erik
2005
Angioødem 2005,;Nielsen, Erik Waage
EEG should be performed during induced hypothermia 2005, Resuscitation:;Hovland, A; Nielsen, Erik Waage; Klüver, J; Salvesen, Rolf