Terhi Hannele Kärpänen
Førsteamanuensis
Fakultet for biovitenskap og akvakultur
PhD in Biomedical Sciences, University of Helsinki, Finland (2006)
Competence areas
- Molecular Biology
- Functional Genetics
- Developmental Biology with focus on early embryonic development
- Lymphangiogenesis, lymphatic tumor metastasis, lymphedema
- Cancer Immunotherapy
BI210F Molecular Cell Biology (lecturer)
Supervision of 1 BSc and 4 MSc theses, currently co-supervision for 3 PhD students
Current research is focused on regulation of early embryonic development by small regulatory RNAs
Publications in Google Scholar
https://scholar.google.com/citations?user=g2h8H30AAAAJ& hl=en
2023
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo 2023, Nature Cancer: Volum 4 Giannakopoulou, Eirini Chrysovalantou; Lehander, Madeleine; Virding Culleton, Stina; Yang, Weiwen; Li, Yingqian; Kärpänen, Terhi Hannele
2017
An evolutionarily conserved role for Polydom/Svep1 during lymphatic vessel formation 2017, Circulation Research: Volum 120 s. 1263-1275 Kärpänen, Terhi Hannele; Padberg, Yvonne; Van De Pavert, Serge A.; Dierkes, Cathrin; Morooka, Nanami; Peterson-Maduro, Josi
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy 2017, Frontiers in Immunology: Kärpänen, Terhi Hannele; Olweus, Johanna
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1 2017, Scientific Reports: Volum 7 Jha, Sawan Kumar; Rauniyar, Khushbu; Kärpänen, Terhi Hannele; Leppanen, Veli-Matti; Brouillard, Pascal; Vikkula, Mikka
2015
T-cell receptor gene therapy - ready to go viral? 2015, Molecular Oncology: Volum 9 s. 2019-2042 Kärpänen, Terhi Hannele; Olweus, Johanna
2014
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis 2014, Development: Le Guen, Ludovic; Kärpänen, Terhi Hannele; Schulte, Dörte; Harris, Nicole C; Koltowska, Katarzyna; Roukens, Guy
CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation 2014, Circulation: Jeltsch, Michael; Jha, Sawan Kumar; Dvorogov, Denis; Anisimov, Andrey; Leppanen, Veli-Matti; Holopainen, Tanja
2013
The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment 2013, Development: Helker, Christian S M; Schuermann, Annika; Kärpänen, Terhi Hannele; Zeuschner, Dagmar; Belting, Heinz-Georg; Affolter, Markus
2011
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor 2011, Blood: Zheng, Wei; Tammela, Tuomas; Yamamoto, Masahiro; Anisimov, Andrey; Holopainen, Tanja; Kaijalainen, Seppo
CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo 2011, Circulation Research: Bos, Frank L; Caunt, Maresa; Peterson-Maduro, Josi; Planaz-Paz, Lara; Kowalski, Joe; Kärpänen, Terhi Hannele
Zebrafish Provides a Novel Model for Lymphatic Vascular Research 2011, Methods in Cell Biology: Kärpänen, Terhi Hannele; Schulte-Merker, Stefan
2010
Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts 2010, Circulation: Nykänen, Antti I; Sandelin, Henrik; Krebs, Reiner; Keränen, Mikko A I; Tuuminen, Raimo; Kärpänen, Terhi Hannele
miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo 2010, Molecular and Cellular Biology: Leslie Pedrioli, Deena M; Kärpänen, Terhi Hannele; Dabouras, Vasilios; Jurisic, Giorgia; Van De Hoek, Glenn; Shin, Jay W.
2008
Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy 2008, Circulation Research: Kärpänen, Terhi Hannele; Bry, Maija; Ollila, Hanna M.; Seppänen-Laakso, Tuulikki; Liimatta, Erkki; Leskinen, Hanna
Molecular Biology and Pathology of Lymphangiogenesis 2008, Annual Review of Pathology: Kärpänen, Terhi Hannele; Alitalo, Kari
VEGF-D: a modifier of embryonic lymphangiogenesis 2008, Blood: Kärpänen, Terhi Hannele; Alitalo, Kari
2007
Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein 2007, Circulation Research: Keskitalo, Salla; Tammela, Tuomas; Lyytikka, Johannes; Kärpänen, Terhi Hannele; Jeltsch, Michael; Markkanen, Johanna
2006
Lymphatic vessels in health and disease: Role of the VEGF-C/VEGFR-3 pathway and the transcription factor FOXC2 2006, Helsinki University Press (HUP): Alitalo, Kari; Kärpänen, Terhi Hannele
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors 2006, The FASEB Journal: Kärpänen, Terhi Hannele; Heckman, Caroline A.; Keskitalo, Salla; Jeltsch, Michael; Ollila, Hanna M.; Neufeld, Gera
Regulation of lymphangiogenesis—From cell fate determination to vessel remodeling 2006, Experimental Cell Research: Kärpänen, Terhi Hannele; Mäkinen, Taija
Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns 2006, Journal of Biological Chemistry: Jeltsch, Michael; Kärpänen, Terhi Hannele; Strandin, Tomas; Aho, Kukka; Lankinen, Hilkka; Alitalo, Kari
Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation 2006, American Journal of Pathology: Kärpänen, Terhi Hannele; Wirzenius, Maria; Mäkinen, Taija; Veikkola, Tanja; Haisma, Hidde J; Achen, Marc G
2005
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries 2005, Gene Therapy: Bhardwaj, S.; Roy, H.; Kärpänen, Terhi Hannele; Hi, Y; Jauhiainen, S; Hedman, M
2004
Role of lymphangiogenic factors in tumor metastasis 2004, Biochimica et Biophysica Acta. CR. Reviews on Cancer: He, Yulong; Kärpänen, Terhi Hannele; Alitalo, Kari
Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells 2004, PNAS: Laakkonen, Pirjo; Åkerman, Maria E; Biliran, Hector; Yang, Meng; Ferrer, Fernando; Kärpänen, Terhi Hannele
PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis 2004, Blood: Uutela, Marko; Wirzenius, Maria; Paavonen, Karri; Rajantie, Iiro; He, Yulong; Kärpänen, Terhi Hannele
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis 2004, Nature Medicine: Petrova, Tatiana V; Kärpänen, Terhi Hannele; Norrmen, Camilla; Mellor, Russell; Tamakoshi, Tomoki; Finegold, David
2002
Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling 2002, Journal of the National Cancer Institute: He, Yulong; Kozaki, Ken-ichi; Kärpänen, Terhi Hannele; Kochikawa, Katsumi; Ylä-Herttuala, Seppo; Takahashi, Takashi
Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome 2002, American Journal of Pathology: Zhou, Yan; McMaster, Michael; Woo, Kirstin; Janatpour, Mary; Perry, Jean; Kärpänen, Terhi Hannele
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors 2002, International Journal of Cancer: Mattila, Mirjami MT; Ruohola, Johanna K; Kärpänen, Terhi Hannele; Jackson, David G; Alitalo, Kari; Härkönen, Pirkko L
2001
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 2001, Nature Medicine: Mäkinen, Taija; Jussila, Lotta; Veikkola, Tanja; Kärpänen, Terhi Hannele; Kettunen, Mikko I; Pulkkanen, Kalevi J
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3 2001, EMBO Journal: Mäkinen, Taija; Veikkola, Tanja; Mustjoki, Satu; Kärpänen, Terhi Hannele; Catimel, Bruno; Nice, Edouard C.
The Drosophila VEGF receptor homolog is expressed in hemocytes 2001, Mechanisms of Development: Heino, Tapio I; Kärpänen, Terhi Hannele; Wahlström, Gudrun; Pulkkinen, Marianne; Eriksson, Ulf; Alitalo, Kari
Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin 2001, Circulation Research: Enholm, Berndt; Kärpänen, Terhi Hannele; Jeltsch, Michael; Kubo, Hajime; Stenback, Frej; Prevo, Remko
Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth 2001, Cancer Research: Kärpänen, Terhi Hannele; Egeblad, Mikala; Karkkainen, Marika J.; Kubo, Hajime; Ylä-Herttuala, Seppo; Jäättelä, Marja
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice 2001, EMBO Journal: Veikkola, Tanja; Jussila, Lotta; Mäkinen, Taija; Kärpänen, Terhi Hannele; Jeltsch, Michael; Petrova, Tatiana V
Lymphatic Vessels as Targets of Tumor Therapy? 2001, Journal of Experimental Medicine (JEM): Kärpänen, Terhi Hannele; Alitalo, Kari
2000
Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis 2000, Oncogene: Saaristo, Anne; Kärpänen, Terhi Hannele; Alitalo, Kari
1999
Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1 1999, Journal of Biological Chemistry: Mäkinen, Taija; Olofsson, Birgitta; Kärpänen, Terhi Hannele; Hellman, Ulf; Soker, Shay; Klagsbrun, Michael
Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers 1999, Journal of Biological Chemistry: Stacker, Steven A; Stenvers, Kaye; Caesar, Carol; Vitali, Angela; Domagala, Teresa; Nice, Edouard C.